Smart Series Nucleic Acid Extractors

TGuide S32 Pro Automated Nucleic Acid Extractor

TGuide S32 Pro is a 1–32 sample automated nucleic acid extraction and purification system based on magnetic bead technology. Designed for research and testing laboratories, it delivers automated DNA, RNA and pathogen nucleic acid extraction while supporting PCR, qPCR and NGS sample preparation workflows for pathogen detection, environmental testing, food safety analysis and biopharmaceutical research.

Catalog Number|Packaging

Mat. No

Ref. No

No. of preps

OSE-S216-AM

OSE-S216-AM 1 set

  • Description

    TGuide S32 Pro is a key system within the SMART automated nucleic acid extraction platform, designed for automated extraction and purification of DNA, RNA and other biomolecules using magnetic bead technology. Supporting automated processing of 1–32 samples per run, it combines throughput, efficiency and workflow flexibility for research, pathogen detection, environmental testing, food safety analysis and biopharmaceutical research.

    As part of the SMART platform, TGuide S32 Pro is compatible with shared reagents, consumables and standardized workflows across multiple throughput configurations, enabling seamless scalability from low-throughput to high-throughput laboratories. The system supports a wide range of applications including genomic DNA extraction, total RNA extraction, pathogen DNA/RNA extraction, environmental microbiome analysis, food DNA extraction, plasmid purification, PCR clean-up, gel extraction and protein purification.

    Equipped with an 8-inch touchscreen, programmable protocols, role-based user management and audit trail functions, TGuide S32 Pro helps laboratories standardize workflows, improve traceability and achieve reproducible sample preparation results for PCR, qPCR and NGS applications.

  • Features

    One Platform, Multiple Throughputs

    Compatible with both strip-based and plate-based SMART prefilled reagent formats, while also supporting standard deep-well plates and commonly used bulk reagent systems. Laboratories can use the same reagents, consumables and workflows across TGuide S16, TGuide S32 Pro and TGuide S96 Dex, simplifying method transfer and supporting laboratory growth without rebuilding extraction workflows.


    Multi-Cycle Magnetic Binding for Reproducible Recovery

    During extraction, magnetic beads remain attached to the magnetic rod through multiple binding and elution cycles, improving bead utilization and nucleic acid recovery. This design reduces bead carryover and supports reproducible recovery from run to run, even with low-volume elution.


    Flexible Workflows, Standardized Results

    When used with TIANGEN prefilled reagent kits, predefined protocols enable rapid deployment and one-click operation for routine applications. The integrated 8-inch touchscreen supports protocol editing and parameter optimization, allowing laboratories to customize workflows for different sample types while maintaining consistent results. The platform can also be adapted for magnetic bead applications such as protein and antibody purification.


    Audit Trail for Complete Sample Traceability

    Role-based user management, barcode integration and run log recording provide complete sample traceability throughout the workflow. Designed for academia, biopharma and testing laboratories requiring standardized operations, data integrity and process accountability.


    Built-In Contamination Control for Clean Runs

    UV sterilization, aerosol control design and fully enclosed operation minimize cross-contamination during sample processing. These features support reliable performance in pathogen detection, environmental monitoring and other high-sensitivity molecular testing workflows.


  • Which SMART Platform Fits Your Laboratory?

    All SMART platforms share the same extraction chemistry, reagent ecosystem and consumable formats. Choose the system that best matches your throughput, workflow and laboratory management requirements.

    Selection Criteria TGuide S16 TGuide S32 Pro
    Platform Position Flexible Automation Platform Core SMART Platform System
    Sample Throughput 1–16 samples 1–32 samples
    Workflow Deployment Ready-to-run workflows Ready-to-run + Custom workflows
    Protocol Development Basic Advanced
    Audit Trail — Yes
    Sample Traceability — Yes
    User Rights Management — Multi-level access control
    Recommended Environment Biosafety cabinets, distributed testing sites, field and mobile laboratories Core facilities, centralized laboratories, testing centers
    Best For Flexible deployment and multi-project workflows Workflow standardization, traceability and laboratory management

    TGuide S16

    Platform Position Flexible Automation Platform
    Sample Throughput 1–16 samples
    Workflow Deployment Ready-to-run workflows
    Protocol Development Basic
    Recommended Environment Biosafety cabinets, distributed testing sites, field and mobile laboratories
    Best For Flexible deployment and multi-project workflows

    TGuide S32 Pro

    Platform Position Core SMART Platform System
    Sample Throughput 1–32 samples
    Workflow Deployment Ready-to-run + Custom workflows
    Protocol Development Advanced
    Audit Trail Yes
    Sample Traceability Yes
    User Rights Management Multi-level access control
    Recommended Environment Core facilities, centralized laboratories, testing centers
    Best For Workflow standardization, traceability and laboratory management
  • Key Applications

    TGuide S32 Pro supports automated nucleic acid extraction and sample preparation workflows for genomics research, pathogen detection, environmental microbiology, food safety testing, plasmid purification and method development. Designed for research institutes, core facilities, biopharmaceutical laboratories and testing laboratories, it helps improve laboratory productivity while maintaining workflow consistency.

    Genomic DNA & RNA Extraction

    Automated extraction of high-quality DNA and RNA from tissues, cells, blood, plants, fungi and other biological samples. Supports downstream applications including PCR, RT-PCR, qPCR, sequencing and NGS library preparation.

    Genomics · Transcriptomics · qPCR · NGS

    Pathogen Detection & Infectious Disease Research

    Automated extraction of pathogen DNA and RNA from serum, plasma, swabs, sputum, stool and tissue samples. Suitable for pathogen surveillance, molecular testing and metagenomic sequencing workflows.

    Pathogen Detection · Molecular Testing · mNGS

    Microbiome & Environmental Research

    Supports DNA extraction from soil, sludge, sediment, stool, water and air filter samples. Ideal for 16S/ITS amplicon sequencing, microbiome studies and metagenomic research.

    16S · ITS · Metagenomics · Microbiome

    Food Safety & Traceability Testing



    Automated DNA extraction from processed food samples for GMO testing, species identification, food authenticity verification and traceability studies.


    GMO Testing · Food Traceability · Species Identification

    Plasmid Purification & PCR Cleanup


    Supports automated plasmid DNA purification, PCR product cleanup and gel extraction workflows for cloning, sequencing, restriction enzyme analysis and NGS library construction.


    Cloning · Sequencing · NGS Library Prep

    Protein Purification & Workflow Development

    Supports protocol development and workflow optimization. Compatible with a variety of magnetic bead chemistries for protein purification and automation applications beyond nucleic acid extraction.

    Method Development · Workflow Optimization · Protein Purification
  • Key Performance Specifications

    Parameter TGuide S32 Pro
    Sample Throughput 1–32 samples
    Sample Processing Volume 20–1000 μL
    Magnetic Bead Recovery Rate ≥98%
    Reproducibility (CV) ≤3%
    Temperature Control Range Ambient +5°C to 120°C
    Audit Trail & User Management Supported
    Custom Protocol Editing Supported
    User Interface 8-inch Full-Color Touchscreen
    Dimensions (W × D × H) 442 × 465 × 385 mm
  • Validated SMART Reagent Selection Guide

    One Chemistry. Two Formats.

    SMART prefilled reagents are available in both Cartridge (48 preps) and Plate (96 preps) formats. Both formats utilize the same extraction chemistry, validated protocols and automated workflows, allowing laboratories to scale throughput without redeveloping extraction methods.

    Workflow SMART Reagent Kit Typical Samples 48 Preps
    (Cartridge)
    96 Preps
    (Plate)
    Genomic DNA Extraction TGuide Smart Universal DNA Kit Tissues, blood, cells, FFPE samples and bacteria GDP605-DE GDP605-E
    Plant DNA Extraction TGuide Smart Hi-Plant DNA Kit Standard and polyphenol-rich plant samples GDP617-DE GDP617-E
    Environmental DNA Extraction TGuide Smart Envir-DNA Kit Soil, stool, sludge, wastewater and air filters GDP613-DE GDP613-E
    Processed Food DNA Extraction TGuide Smart Processed Food DNA Kit Processed foods, meat products, starches, honey, chocolate and pet food GDP680-DE GDP680-E
    Viral DNA/RNA Extraction TGuide Smart Viral DNA/RNA Kit Viral transport media (VTM), serum, plasma and wastewater samples GDP604-DE GDP604-E
    Total RNA Extraction TGuide Smart Universal RNA Kit Tissues, cells, blood, bacteria, fungi, swabs and food-related samples.
    Validated on 600+ sample types.
    GDP671-DE GDP671-E
    Plant RNA Extraction TGuide Smart Hi-Plant RNA Kit Standard plants, polyphenol-rich plants and fungal samples.
    Validated on 1,000+ sample types.
    GDP672-DE GDP672-E
    PCR Cleanup & Gel Extraction TGuide Smart DNA Purification Kit PCR products, enzymatic reactions and agarose gel fragments GDP642-DE —
    Plasmid DNA Purification TGuide Smart Mini Plasmid Kit Bacterial cultures GDP641-DE GDP641-E
    Low-Input RNA Extraction TGuide Smart Micro Cell Total RNA Kit Low-input and limited cell samples GDP670-DE GDP670-E

    Genomic DNA Extraction

    Kit: TGuide Smart Universal DNA Kit

    Samples: Tissues, blood, cells, FFPE samples and bacteria

    Cartridge: GDP605-DE

    Plate: GDP605-E

    Plant DNA Extraction

    Kit: TGuide Smart Hi-Plant DNA Kit

    Samples: Standard and polyphenol-rich plant samples

    Cartridge: GDP617-DE

    Plate: GDP617-E

    Environmental DNA Extraction

    Kit: TGuide Smart Envir-DNA Kit

    Samples: Soil, stool, sludge, wastewater and air filters

    Cartridge: GDP613-DE

    Plate: GDP613-E

    Processed Food DNA Extraction

    Kit: TGuide Smart Processed Food DNA Kit

    Samples: Processed foods, meat products, starches, honey, chocolate and pet food

    Cartridge: GDP680-DE

    Plate: GDP680-E

    Viral DNA/RNA Extraction

    Kit: TGuide Smart Viral DNA/RNA Kit

    Samples: VTM, serum, plasma and wastewater samples

    Cartridge: GDP604-DE

    Plate: GDP604-E

    Total RNA Extraction

    Kit: TGuide Smart Universal RNA Kit

    Samples: Tissues, cells, blood, bacteria, fungi, swabs and food-related samples

    Validation: 600+ sample types validated

    Cartridge: GDP671-DE

    Plate: GDP671-E

    Plant RNA Extraction

    Kit: TGuide Smart Hi-Plant RNA Kit

    Samples: Standard plants, polyphenol-rich plants and fungal samples

    Validation: 1,000+ sample types validated

    Cartridge: GDP672-DE

    Plate: GDP672-E

    PCR Cleanup & Gel Extraction

    Kit: TGuide Smart DNA Purification Kit

    Samples: PCR products, enzymatic reactions and agarose gel fragments

    Cartridge: GDP642-DE

    Plasmid DNA Purification

    Kit: TGuide Smart Mini Plasmid Kit

    Samples: Bacterial cultures

    Cartridge: GDP641-DE

    Plate: GDP641-E

    Low-Input RNA Extraction

    Kit: TGuide Smart Micro Cell Total RNA Kit

    Samples: Low-input and limited cell samples

    Cartridge: GDP670-DE

    Plate: GDP670-E

    Choosing the Right Format

    • Choose Cartridge kits (48 preps) for flexible sample numbers and maximum workflow flexibility.
    • Choose Plate kits (96 preps) for larger sample batches and higher throughput.
    • Both formats use identical extraction chemistry, validated workflows and performance specifications.

    Why SMART Reagents?

    • Validated on both TGuide S16 and TGuide S32 Pro platforms.
    • Available in Cartridge (48 preps) and Plate (96 preps) formats.
    • Identical extraction chemistry and workflow performance across formats.
    • Support genomics, transcriptomics, microbiome research, pathogen detection and food safety testing.
    • Enable throughput expansion without redeveloping extraction methods.
    SMART Automation Platform

    1,000+ Installed Systems   |   8 Million+ Customer Extractions
  • FAQ

    Frequently Asked Questions

    Frequently asked questions about SMART workflows, audit trails, sample traceability, protocol development and automated DNA/RNA extraction using TGuide S32 Pro.

    What types of laboratories is TGuide S32 Pro designed for?
    TGuide S32 Pro is designed for research laboratories, shared core facilities, biopharmaceutical R&D laboratories and testing laboratories that require medium-throughput sample processing, workflow standardization and traceability.
    How is TGuide S32 Pro different from TGuide S16?
    Both instruments use the same SMART extraction chemistry, reagent formats and workflows. TGuide S16 is optimized for flexible deployment and smaller sample batches, while TGuide S32 Pro provides higher throughput, audit trail functionality, user-right management and advanced workflow development capabilities.
    Which SMART platform should I choose?
    TGuide S16 is ideal for laboratories requiring flexible deployment and smaller sample batches. TGuide S32 Pro is designed for laboratories requiring workflow standardization, audit trails and medium-throughput processing. Laboratories requiring higher throughput and large-scale sample processing should consider TGuide S96 Dex where available.
    What advantages does the SMART platform provide?
    The SMART platform enables laboratories to use the same extraction chemistry, reagent kits and consumables across multiple throughput configurations. Laboratories can scale from TGuide S16 to TGuide S32 Pro without redeveloping extraction protocols.
    Which SMART workflows are available on TGuide S32 Pro?
    Validated SMART workflows include genomic DNA extraction, RNA extraction, pathogen DNA/RNA extraction, microbiome research, food safety testing, plasmid purification, PCR cleanup and gel extraction workflows.
    Which sample types are supported?
    TGuide S32 Pro supports a broad range of biological and environmental samples including tissues, cells, blood, swabs, bacteria, fungi, plants, wastewater, soil, stool, FFPE samples, processed food products and many other validated sample types.
    Does TGuide S32 Pro support custom protocol development?
    Yes. The system supports protocol editing and parameter optimization, allowing laboratories to develop, validate and optimize automated workflows for specific applications and sample types.
    Is audit trail functionality available?
    Yes. TGuide S32 Pro includes audit trail functionality, user-right management and optional barcode integration for sample traceability and standardized laboratory operation.
    Can TGuide S32 Pro be used for NGS sample preparation workflows?
    Yes. DNA and RNA purified with SMART extraction kits can be used in downstream applications including PCR, qPCR, NGS library preparation, pathogen detection and microbiome research workflows.
    How do I choose between Cartridge and Plate reagent formats?
    Cartridge kits (48 preps) are recommended for laboratories processing variable sample numbers and requiring maximum workflow flexibility. Plate kits (96 preps) are suitable for larger sample batches and higher-throughput processing. Both formats use the same extraction chemistry and validated workflows.

Experimental Example

Results: Total RNA extracted from animal tissues using TGuide S32 Pro and the TGuide Smart Universal RNA Kit (GDP671) showed yield and purity comparable to a conventional spin-column based extraction method. RNA purity was consistently high, with OD260/OD280 ratios of approximately 2.0–2.1 and OD260/OD230 values above 2.0. The results demonstrate that the SMART automated workflow provides equivalent RNA quality while reducing hands-on time and enabling standardized sample processing.

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