The TGuide S96 Automated Nucleic Acid Extractor is a versatile automated platform for high-throughput and large-volume purification of DNA and RNA. Built on proven magnetic bead technology, it delivers reliable recovery, high purity, and consistent performance across a wide range of sample preparation workflows.

The system processes up to 96 samples simultaneously and can be expanded to handle up to 192 samples in a single run, making it an efficient solution for laboratories managing high sample volumes and demanding throughput requirements.

For applications requiring greater sample input, an optional 24-position large-volume module supports processing volumes of up to 5 mL per sample. This flexibility enables efficient extraction from plasma, serum, whole blood, urine, and other low-abundance specimens, making the system well suited for cell-free DNA (cfDNA) studies, liquid biopsy research, and molecular diagnostic workflows.

Combined with TIANGEN prefilled reagent kits and validated extraction protocols, the platform supports automated DNA and RNA purification from diverse sample types, including clinical, animal, plant, microbial, soil, and environmental samples. The TGuide S96 provides a scalable and reliable solution for molecular diagnostics, genomics, NGS sample preparation, agricultural biotechnology, and environmental research.

The TGuide S96 supports automated DNA and RNA extraction from a broad range of biological, clinical, agricultural, and environmental samples.

• Blood & Liquid Samples
  Whole blood, plasma, serum, urine, and other biological fluids
• Cells & Tissues
  Cultured cells, animal tissues, and clinical specimen samples
• Microbial Samples
  Bacteria, fungi, viruses, and environmental microorganisms
• Plant Samples
  Plant tissues, leaves, seeds, roots, and polysaccharide- or polyphenol-rich plant materials
• Animal Samples
  Animal tissues, blood samples, and veterinary specimens
• Environmental Samples
  Soil, sediment, wastewater, sludge, and other environmental monitoring samples
• Low-Abundance Samples
  Cell-free DNA (cfDNA), circulating nucleic acids, and other trace nucleic acid samples

• Molecular Diagnostics
  Automated purification of DNA and RNA for pathogen detection, infectious disease testing, and clinical molecular workflows.


• Liquid Biopsy and Cell-Free DNA (cfDNA) Analysis
  Large-volume extraction capability enables efficient recovery of low-abundance nucleic acids from plasma and serum samples for liquid biopsy research and cell-free DNA applications.


• Genomics and NGS Sample Preparation
  High-quality nucleic acid extraction for next-generation sequencing (NGS), genomic research, library preparation, and precision medicine studies.


• Environmental Microbiology Research
  Automated extraction of microbial DNA and RNA from soil, sediment, wastewater, sludge, and other environmental samples for monitoring and biodiversity studies.


• Agricultural Biotechnology and Plant Research
  Efficient purification of nucleic acids from plant tissues, seeds, roots, and challenging polysaccharide- and polyphenol-rich samples for crop research and breeding programs.


• Animal and Veterinary Research
  Extraction of DNA and RNA from animal tissues, blood, and veterinary samples for disease research, breeding, and diagnostic applications.


• Microbial and Pathogen Studies
  Rapid nucleic acid extraction from bacteria, fungi, viruses, and other microorganisms for microbiology, infectious disease, and public health research.


• Biobanking and Large-Scale Research Projects
  Scalable sample preparation for population studies, biobanks, epidemiological research, and other high-throughput laboratory workflows.

Selection depends on sample volume, testing frequency, workflow complexity, and throughput requirements. The Smart Series instruments (TGuide S16 and TGuide S32 Pro) are ideal for flexible and easy-to-use automation, while the TGuide S96 is optimized for high-throughput workflows and optional large-volume sample processing.