Smart Series Nucleic Acid Extractors

TGuide S16 Nucleic Acid Extractor

A compact automated nucleic acid extraction system for flexible 1–16 sample processing, supporting multiple DNA and RNA extraction workflows.

Catalog Number|Packaging

Mat. No

Ref. No

No. of preps

OSE-S16-AM

OSE-S16-AM 1 set

  • Description

    TGuide S16 is a compact automated nucleic acid extraction system designed for flexible, on-demand DNA and RNA purification. Based on magnetic bead technology, it processes 1–8 or 16 samples per run, allowing laboratories to start extraction without waiting to fill a larger batch.

    With a footprint of only 208 × 258 mm, TGuide S16 fits easily into space-constrained laboratory environments and can be deployed in suitable biosafety cabinets and clean benches. Its compact design also enables multiple instruments to be used in parallel for different extraction workflows when laboratories require greater workflow flexibility.

    TGuide S16 is compatible with TIANGEN SMART prefilled Cartridge and Plate reagent formats and supports ready-to-run workflows for genomic DNA, total RNA, miRNA, pathogen DNA/RNA, environmental samples, food samples, plasmid DNA and PCR cleanup. Users load prepared samples, select a predefined protocol and start the run, reducing hands-on time and operator-dependent variation.

    As part of the SMART automated nucleic acid extraction platform, TGuide S16 shares extraction chemistry, reagents and consumables with TGuide S32 Pro. Laboratories can therefore expand processing capacity while maintaining established extraction workflows and reducing method transfer and retraining requirements.

  • Ready-to-Run Automation with Minimal Hands-On Steps

    The TGuide S16 workflow simplifies automated DNA and RNA extraction with SMART prefilled reagents and predefined protocols. From sample loading to purified nucleic acid collection, the extraction process is automated to minimize manual setup and hands-on operation, helping laboratories get started quickly while improving workflow consistency.

    TGuide S16 automated nucleic acid extraction workflow showing sample loading, automated extraction and purified DNA/RNA collection

             TGuide S16 Automated Nucleic Acid Extraction Workflow


  • Key Features

    TGuide S16 combines compact deployment, flexible 1–16 sample processing and SMART prefilled reagents for on-demand automated DNA and RNA extraction.

    Compact Footprint for Flexible Deployment

    At only 208 × 258 × 315 mm, TGuide S16 fits easily into space-constrained laboratories and can be deployed on laboratory benches or, where conditions are suitable, in biosafety cabinets and clean benches.

    Compact Footprint · Benchtop · Biosafety Cabinet

    Flexible 1–16 Sample Processing

    Process 1–8 or 16 samples per run without waiting to fill a larger batch, supporting on-demand extraction, variable daily workloads and multiple research projects.


    1–16 Samples · On-Demand · Variable Batch Size

    Prefilled Reagents Reduce Hands-On Setup

    Ready-to-use SMART prefilled reagents reduce manual dispensing, preparation time and handling steps while helping minimize contamination risks. No dedicated reagent dispensing instrument is required.

    Prefilled Reagents · Less Manual Dispensing · No Dispenser Required

    Cartridge or Plate to Match Your Workload

    Use Cartridge-format prefilled reagents for smaller or variable batches and Plate-format reagents for larger batches. Both formats use the same extraction chemistry and established SMART workflows.


    Cartridge · Plate · Flexible Batch Processing

    Multi-Cycle Magnetic Collection for Efficient Recovery

    Multi-cycle magnetic collection concentrates beads around the magnetic rod tip, supporting efficient bead recovery and effective elution even at low elution volumes while minimizing bead loss.

    Multi-Cycle Collection · Bead Recovery · Low-Volume Elution

    Built-In Contamination Control

    Enclosed operation, an anti-aerosol fan and UV decontamination help reduce aerosol residue and cross-contamination risks in pathogen and molecular testing workflows.


    UV Decontamination · Aerosol Control · Enclosed Operation
  • Featured SMART Workflows

    Explore selected SMART workflows for universal DNA extraction, routine and challenging RNA samples, environmental microbiome and eDNA research, and food safety applications.

    GDP605 automated genomic DNA extraction for tissues, cells, blood, swabs, FFPE and bacteria

    Universal Genomic DNA Extraction

    GDP605 provides automated genomic DNA extraction from tissues, cells, blood, swabs, FFPE and bacteria. Purified DNA supports PCR, qPCR and sequencing.

    GDP605 · Tissue · Cells · Blood · Swabs · FFPE · Bacteria
    Explore DNA Workflow →
    GDP671 and GDP672 automated RNA extraction for routine, lipid-rich animal, plant and fungal samples

    RNA Extraction for Routine & Challenging Samples

    GDP671 supports total RNA extraction from routine and lipid-rich animal samples, including brain and adipose tissue. GDP672 targets challenging plant and fungal samples rich in polysaccharides and polyphenols.

    GDP671 · 600+ Validated Sample Types
    GDP672 · 1,000+ Validated Plant & Fungal Sample Types
    View RNA Performance →
    GDP613 environmental microbiome and eDNA extraction for soil, stool, wastewater and water filter samples

    Environmental Microbiome & eDNA Extraction

    GDP613 supports DNA extraction from soil, stool, sludge, wastewater and water filter samples, including aquatic eDNA research. Purified DNA supports 16S/ITS sequencing, metabarcoding and metagenomics.

    GDP613 · Soil · Stool · Wastewater · eDNA · 16S/ITS · Metabarcoding
    Explore Environmental & eDNA →
    GDP680 automated food DNA extraction for processed food, dairy, foodborne pathogen testing and GMO analysis

    Food DNA Extraction & Food Safety Testing

    GDP680 supports DNA extraction from processed foods, meat, dairy products and fermentation biomass. Purified DNA supports food authenticity, species identification, GMO analysis and molecular testing of foodborne pathogens.

    GDP680 · Processed Food · Dairy · Foodborne Pathogens · GMO · Species Identification
    Explore Food DNA Workflows →
  • Supported Sample Types

    This instrument is suitable for the extraction and purification of nucleic acids in animals, plants, bacteria, cultured cells, blood, plasmids, viruses, etc. 

    Cell
    Tissue
    Blood
    Swab
    Virus
    Bacteria
    Insects
    DBS
    Soil/Feces
    Sewage
    Fungi
    Plant
    Plasmid
    PCR / Gel Recovery
    FFPE
    Food

  • Parameters

    Parameter TGuide S16
    Sample Throughput 1–8 or 16 samples per run
    Processing Volume 20–1,000 μL
    Reagent Formats SMART prefilled Cartridge and Plate reagents
    Extraction Reproducibility CV ≤5%
    Lysis/Elution Temperature Range Ambient to 120°C
    Temperature Accuracy ±1°C
    Heating Time ≤5 min from ambient to 120°C
    User Interface 4.3-inch touchscreen; mobile app control
    Protocol Storage Up to 100 protocols
    Contamination Control Anti-aerosol fan and UV decontamination
    Power Options DC 24 V input; AC 100–240 V, 50/60 Hz adapter; battery-powered operation supported
    Dimensions (W × D × H) 208 × 258 × 315 mm
  • SMART Workflow & Reagent Selection Guide

    One Reagent Ecosystem. Multiple Throughputs.

    The same SMART reagent kits and consumables can be used across TGuide S16 and TGuide S32 Pro. Consistent protocol IDs across compatible instruments allow users to select the corresponding preloaded protocol and start the run without manually transferring or redeveloping extraction methods.

    Laboratories can scale from flexible, on-demand processing to higher-throughput automation while maintaining the same reagents, consumables and familiar operating workflow.

    SMART Cartridge-Format Prefilled Reagents

    Cartridge-Format Prefilled Reagents

    For smaller or variable sample batches and flexible, on-demand processing.

    48 preps per kit
    SMART Plate-Format Prefilled Reagents

    Plate-Format Prefilled Reagents

    For larger sample batches and simplified reagent preparation.

    96 preps per kit
    Workflow SMART Reagent Kit Typical Samples 48 Preps
    (Cartridge)
    96 Preps
    (Plate)
    Genomic DNA Extraction TGuide Smart Universal DNA Kit Tissues, blood, cells, FFPE samples and bacteria GDP605-DE GDP605-E
    Plant DNA Extraction TGuide Smart Hi-Plant DNA Kit Standard and polyphenol-rich plant samples GDP617-DE GDP617-E
    Environmental DNA Extraction TGuide Smart Envir-DNA Kit Soil, stool, sludge, wastewater and air filters GDP613-DE GDP613-E
    Processed Food DNA Extraction TGuide Smart Processed Food DNA Kit Processed foods, meat products, starches, honey, chocolate and pet food GDP680-DE GDP680-E
    Viral DNA/RNA Extraction TGuide Smart Viral DNA/RNA Kit Viral transport media, serum, plasma and wastewater samples GDP604-DE GDP604-E
    Total RNA Extraction TGuide Smart Universal RNA Kit Tissues, cells, blood, bacteria, fungi, swabs and food-related samples.
    Validated across 600+ sample types.
    GDP671-DE GDP671-E
    Plant RNA Extraction TGuide Smart Hi-Plant RNA Kit Standard plants, polyphenol-rich plants and fungal samples.
    Validated across 1,000+ plant and fungal sample types.
    GDP672-DE GDP672-E
    PCR Cleanup & Gel Extraction TGuide Smart DNA Purification Kit PCR products, enzymatic reactions and agarose gel fragments GDP642-DE —
    Plasmid DNA Purification TGuide Smart Mini Plasmid Kit Bacterial cultures GDP641-DE GDP641-E
    Low-Input RNA Extraction TGuide Smart Micro Cell Total RNA Kit Low-input and limited cell samples GDP670-DE GDP670-E

    Choosing the Right Format

    • Choose Cartridge kits for smaller or variable sample batches and flexible, on-demand processing.
    • Choose Plate kits for larger sample batches and simplified reagent preparation.
    • Both formats use the same SMART extraction chemistry, reagent system and established workflows.
    • Pack size indicates the total number of preparations supplied per kit, not the instrument’s per-run sample capacity.

    One Workflow Across Compatible SMART Instruments

    • The same SMART reagent kits and consumables support TGuide S16 and TGuide S32 Pro.
    • Consistent protocol IDs provide a familiar operating workflow across compatible instruments.
    • Users select the corresponding preloaded protocol and start the run without manually transferring or redeveloping extraction methods.
    • Laboratories can expand processing capacity while maintaining established reagents, consumables and extraction workflows.
    SMART Automation Platform
    1,000+ Installed Systems   |   8 Million+ Customer Extractions
  • Regulatory Status

    CE marking under the EU Radio Equipment Directive for TGuide S16  CE marked under the EU Radio Equipment Directive (RED).

    CE-IVD marking for TGuide S16 in vitro diagnostic use  CE-IVD marked for in vitro diagnostic use.

    Regulatory status and product availability may vary by country or region. Please contact your local TIANGEN representative for details.

  • FAQ

    Find answers about sample throughput, SMART prefilled reagents, supported applications, contamination control, platform scalability and regulatory status for the TGuide S16 automated nucleic acid extraction system.

    1. What is TGuide S16, and which laboratories is it designed for?

    TGuide S16 is a compact, magnetic bead-based system for automated DNA and RNA extraction. It is designed for research, molecular testing and smaller testing laboratories that need flexible, on-demand automation without waiting to accumulate a large sample batch.

    With dimensions of 208 × 258 × 315 mm, TGuide S16 is particularly well suited to laboratories with limited bench space or variable daily sample volumes.

    2. How many samples can TGuide S16 process per run?

    TGuide S16 processes 1–8 or 16 samples per run. Laboratories can begin extraction with a small number of samples instead of waiting to fill a larger batch, making the system suitable for on-demand testing, variable daily workloads and laboratories running multiple projects.

    3. Does TGuide S16 require manual reagent dispensing?

    SMART prefilled reagent kits reduce routine manual reagent dispensing, preparation time and handling steps. No dedicated reagent dispensing instrument is required for routine setup.

    Cartridge-format reagents are suitable for smaller or variable sample batches, while Plate-format reagents simplify preparation for larger workloads. Cartridge and Plate pack sizes indicate the total number of preparations supplied per kit, not the instrument’s per-run sample capacity.

    4. How should a laboratory choose between TGuide S16 and TGuide S32 Pro?

    TGuide S16 is well suited to laboratories that prioritize compact deployment, flexible small-batch processing and on-demand extraction. TGuide S32 Pro is better suited to laboratories that require higher throughput and standardized routine processing.

    Both instruments use the same SMART reagent kits, consumables and validated extraction workflows. Corresponding preloaded protocols share consistent protocol IDs, while instrument-specific operating parameters are already optimized for each platform. Users simply select the appropriate protocol and start the run, allowing laboratories to move between flexible small-batch and higher-throughput processing without re-optimizing parameters or re-establishing experimental conditions.

    Under equivalent sample and workflow conditions, the platform is designed to support consistent and comparable extraction performance across the two instruments.

    5. What sample types and extraction workflows does TGuide S16 support?

    Available SMART workflows support genomic DNA, total RNA, plant DNA and RNA, viral DNA/RNA, environmental DNA, processed-food DNA, plasmid DNA, low-input RNA, PCR cleanup and gel extraction.

    Compatible sample types include tissues, cultured cells, blood, swabs, bacteria, viruses, plants, fungi, FFPE samples, soil, stool, wastewater, food samples, bacterial cultures, PCR products and agarose gel fragments. The appropriate SMART reagent kit should be selected according to the sample type, target nucleic acid and downstream application.

    6. Can TGuide S16 process challenging RNA, environmental and food samples?

    Yes. GDP671 supports total RNA extraction from routine biological samples and lipid-rich animal tissues, including brain and adipose tissue. GDP672 is designed for plant and fungal samples rich in polysaccharides, polyphenols and starch.

    GDP613 supports environmental microbiome and environmental DNA (eDNA) workflows for samples including soil, stool, sludge, wastewater and filtered water samples. GDP680 supports DNA extraction from processed foods, meat products, dairy products, fermentation biomass and other challenging food matrices.

    7. What contamination-control features are built into TGuide S16?

    TGuide S16 combines enclosed automated operation, an anti-aerosol fan and UV decontamination to help reduce aerosol residue and cross-contamination risks during sample processing.

    These built-in features support molecular workflows in which contamination control is particularly important, including pathogen-related and other sensitive nucleic acid testing applications. Appropriate laboratory practices and workflow-specific contamination controls should still be followed.

    8. What is the regulatory status of TGuide S16?

    TGuide S16 model OSE-S16-AM is listed with CE RED and CE IVD regulatory records. CE RED relates to conformity with the EU Radio Equipment Directive, while CE IVD applies to the in vitro diagnostic configuration.

    Regulatory status, intended use, applicable configuration and product availability may vary by country or region. Customers should confirm the current regulatory status and appropriate product configuration with their local TIANGEN representative before ordering or using the instrument for diagnostic applications.

  • Free Trial Program

    The Free Trial Program is opened for the TGuide S16 Nucleic Acid Extractor.

    Inquire directly to learn more details. Or fill out the request form (https://forms.gle/vhkYj2f5Uezhpis49) to gain access to the application.

    Open Region: United States, Singapore, Hongkong, etc. (Coming soon for other regions).

Experimental Example

Experiment result: using TGuide S16 with reagent TGuide Smart Universal DNA Kit (4993704)

to automatically extract the genomic DNA of multiple samples including cell,

tissue, blood, dried blood spot (DBS) , Lactobacillus, E.coli, saliva, and swab,etc,

achieved good yield and high purity. The OD260/OD280 around 1.7~1.9, and

OD260/OD230>1.6.

Elution volume:100 μl

Agarose gel concentration:1.5%

Loading volume:1 μl


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