High-throughput Tissue Homogenizers
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TGrinder H24R Tissue Homogenizer
TGrinder H24R is a benchtop tissue homogenizer with integrated low-temperature cooling, designed for efficient sample preparation and tissue disruption while preserving DNA and RNA integrity. It is ideal for heat-sensitive samples and enables reliable nucleic acid extraction with improved downstream performance.
InquireCatalog Number｜Packaging
Mat. No |
Ref. No |
No. of preps |
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OSE-TH-02-AM |
OSE-TH-02-AM | 1 Set |
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Description
TGrinder H24R benchtop low-temperature tissue homogenizer with integrated cooling for DNA, RNA and protein sample preparation without liquid nitrogen
The TGrinder H24R Tissue Homogenizer uses a three-dimensional, high-speed vibration mode to process 1–24 individual samples simultaneously. A built-in compressor enables active cooling without the use of liquid nitrogen, helping prevent the degradation or denaturation of heat-sensitive molecules.
A lid-mounted vortex fan ensures uniform temperature distribution within the chamber. When used with appropriate grinding media, including zirconia beads, stainless steel beads, ceramic beads and glass beads, the system efficiently grinds, lyses and homogenizes a wide range of biological samples such as plant tissue, animal tissue, soil and fecal samples.
In combination with suitable extraction reagents, TGrinder H24R supports rapid and stable extraction of DNA, RNA and proteins while preserving molecular integrity.
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Features
- Sample throughput: Processes 1–24 samples simultaneously, supporting high‑throughput and efficient homogenization workflows.
- Motion mode: Three‑dimensional vibration mode enables thorough and uniform homogenization.
- Fast grinding: Typical sample homogenization can be completed within 30–60 seconds.
- Grinding performance: Provides strong and consistent grinding results with uniform sample processing and no cross‑contamination.
- Low noise and durability: Wear‑resistant mechanical design with low operating noise, suitable for routine laboratory use.
- Cooling function: Active cooling down to −10 °C creates a low‑temperature environment that effectively prevents nucleic acid degradation and protein denaturation during homogenization.
- Safe and reliable operation: Lid‑lock design combined with an automatic braking mechanism enhances operational safety.
- Preinstalled programs: Preset programs provide convenient and complete processing solutions for different sample types.
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Specifications
Product specifications of the TGrinder H24R tissue homogenizer are listed below.
Parameter Specification Catalog number TGrinder H24R Temperature setting range -10°C ~ 40°C Time required for room temperature to drop to 0°C < 30 min Temperature accuracy ±2°C Vibration linear velocity 4.00–7.00 m/s, in 0.05 m/s increments Motor speed 2430–4260 rpm, in 10 rpm increments Time setting Running time: 1–90 sec
Pause time: 1–120 sec
Cycles: 10 timesProgram storage 3 preset programs, 47 custom programs Sample capacity and compatible holders 24 × 2 mL grinding tube holder (standard)
12 × 5 mL grinding tube holder (optional)
24 × 1.5 mL grinding tube holder (optional)Acceleration / deceleration time < 4 sec Noise level ≤ 65 dB Power supply AC 100–240 V, 50/60 Hz Dimensions (W × D × H) 330 × 525 × 420 mm Weight 25 kg -
Applications and Sample Types
The TGrinder H24R is designed for efficient homogenization of biological samples prior to DNA, RNA, protein and other biomolecule extraction.
- Plant tissues: roots, stems, leaves, petals, fruits and seeds
- Animal tissues: heart, liver, spleen, stomach, kidney, lung, intestine and brain
- Complex samples: fish, shrimp, seaweed, soil, fecal and environmental samples
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TGrinder H24R vs Manual Liquid Nitrogen Grinding
Compared with manual liquid nitrogen grinding, the TGrinder H24R provides a safer, faster and more standardized sample preparation workflow while maintaining nucleic acid and protein integrity through active low-temperature control.
Feature TGrinder H24R Manual Liquid Nitrogen Grinding Consistency High Medium Safety High Low Processing Speed Fast Slow Automation Yes No Cooling Method Active cooling to −10°C External liquid nitrogen (-196°C) Sample Throughput Up to 24 samples simultaneously One sample at a time Workflow Standardization High Operator dependent RNA Protection Excellent Good Laboratory Safety No cryogenic handling required Requires liquid nitrogen handling The integrated refrigeration system of the TGrinder H24R allows efficient homogenization of heat-sensitive samples without routine use of liquid nitrogen, helping improve workflow consistency and reducing operational complexity in molecular biology laboratories.
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FAQ
What is a refrigerated tissue homogenizer?
A refrigerated tissue homogenizer is a laboratory instrument that disrupts biological samples while maintaining low temperatures to protect DNA, RNA and proteins from heat-induced degradation during sample preparation.Why is TGrinder H24R suitable for DNA, RNA and protein extraction?
TGrinder H24R combines active cooling down to −10°C with high-speed three-dimensional homogenization. This enables efficient tissue disruption while minimizing heat-induced degradation of DNA, RNA and proteins, making it ideal for molecular biology, genomics, transcriptomics and proteomics workflows.Can TGrinder H24R replace liquid nitrogen grinding?
For many plant, animal and microbial samples, TGrinder H24R can replace conventional liquid nitrogen grinding by providing active cooling down to −10°C during homogenization while preserving nucleic acid and protein integrity. This helps simplify workflows and reduce cryogenic handling requirements.What sample types can be processed using TGrinder H24R?
TGrinder H24R is suitable for plant tissues, animal tissues, bacteria, fungi, soil, fecal samples and other biological materials commonly used in molecular biology, agricultural research, environmental testing and life science applications.How many samples can be processed simultaneously?
The TGrinder H24R can process up to 24 samples simultaneously using standard 2 mL grinding tube holders, significantly improving throughput and experimental consistency.Is TGrinder H24R suitable for RNA extraction?
Yes. The integrated cooling system and high-speed homogenization technology help maintain RNA integrity and support high-quality downstream applications, including RT-PCR, RT-qPCR, RNA sequencing and gene expression analysis.What grinding beads are compatible with TGrinder H24R?
TGrinder H24R is compatible with zirconia beads, stainless steel beads, ceramic beads and glass beads, allowing efficient homogenization of a wide variety of biological sample types.What is the difference between a tissue homogenizer and a bead mill homogenizer?
A tissue homogenizer is a general term for instruments used to disrupt and homogenize biological samples. A bead mill homogenizer is a type of tissue homogenizer that uses high-speed shaking and grinding beads to mechanically break down tissues and cells. TGrinder H24R combines bead mill technology with active refrigeration, providing efficient homogenization while protecting DNA, RNA and proteins from heat-induced degradation.What is the best tissue homogenizer for RNA extraction?
An ideal tissue homogenizer for RNA extraction should efficiently disrupt samples while minimizing heat generation that can damage RNA. TGrinder H24R combines high-speed three-dimensional bead mill homogenization with active cooling down to −10°C, helping preserve RNA integrity and supporting high-quality downstream applications such as RT-qPCR, RNA sequencing and gene expression analysis. -
Certification
CE marked.
Intended for laboratory sample preparation as part of downstream molecular analysis workflows.
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Recommended Products for Downstream
- TIANamp Genomic DNA Kit （Manual spin-column kit for the purification of genomic DNA from whole blood, cultured cells and animal tissues.）
- TGuide Smart Universal RNA Kit（Prefilled extraction kit for automated purification of high-quality total RNA from cultured cells, blood and animal tissues, optimized for challenging samples with high fat content or viscosity.)
- TGuide Smart Envir-DNA Kit (A prefilled extraction kit for the purification of microbial genomic DNA from a broad range of complex, inhibitor-rich environmental samples, including soil, feces, sludge, sediment and water.)
- TGuide S16 Nucleic Acid Extractor (Automated nucleic acid extraction system for low-throughput purification of DNA and RNA from biological and environmental samples, supporting standardized downstream molecular biology workflows.)
- TGuide S32 Pro Automated Nucleic Acid Extractor (High-throughput automated nucleic acid extraction system utilizing magnetic bead technology for fast, reliable and high-quality purification of DNA and RNA from a wide range of sample types.)
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Experimental Example
Experimental example: Plant RNA extraction
Total RNA was extracted from plant tissue samples after homogenization using theTGrinder H24R Tissue Homogenizer. For comparison, parallel samples were processed by manual grinding in liquid nitrogen.
Sample input: 100 mg per sample Plant samples: Peanut, Edamame, Tomato (fruit), Strawberry (fruit)
Agarose gel electrophoresis analysis shows that RNA obtained after TGrinder H24R homogenization displays clear and well‑defined rRNA bands with consistent band patternsacross different plant tissues. Compared with manual liquid nitrogen grinding, TGrinder H24R homogenization provides comparable or improved RNA concentration andpurity under the tested conditions.
Marker: DNA Marker III (TIANGEN, GMD103‑02) RNA extraction kit: TIANGEN RNA Easy Fast Plant Tissue Kit (GDP452)
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